{"id":1917,"date":"2026-03-17T08:00:15","date_gmt":"2026-03-17T07:00:15","guid":{"rendered":"https:\/\/dualdur.com\/?p=1917"},"modified":"2026-04-14T19:44:29","modified_gmt":"2026-04-14T17:44:29","slug":"dualdur","status":"publish","type":"post","link":"https:\/\/dualdur.com\/en\/2026\/03\/17\/dualdur\/","title":{"rendered":"DualDur - the role of direct diagnostics in Lyme disease detection"},"content":{"rendered":"

The diagnosis of Lyme borreliosis remains one of the greatest challenges in infectious diseases. This is not only due to the diverse clinical presentation of the disease, but also to the biological specificity of the pathogen and its complex interaction with the immune system. The traditional diagnostic approach is based primarily on serological methods based on the detection of the immune response. However, in recent years, increasing attention has been paid to methods that directly investigate the presence of the pathogen.<\/p>\n\n\n\n

The direct diagnostic approach is based on the recognition that the most direct evidence of the presence of infection is the detection of the microorganism itself. The DualDur test fits into this diagnostic direction and is designed to provide additional information for clinical decision-making in cases where Lyme borreliosis is suspected.<\/p>\n\n\n\n

Biological features of Lyme borreliosis<\/h2>\n\n\n\n

The causative agents of Lyme disease are bacteria belonging to the Borrelia burgdorferi sensu lato complex, which are spiral or undulating microorganisms. Their morphology is characterised by a characteristic movement that allows them to actively spread between tissues.<\/p>\n\n\n\n

The infection enters the human body through a tick bite. When the tick feeds, the pathogen can enter the host through saliva or contact with the digestive tract and then migrate through the bloodstream to various tissues.<\/p>\n\n\n\n

\n
\n
\n
\n
\"\"<\/figure>\n<\/figure>\n<\/div>\n\n\n\n
\n
\"\"<\/figure>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n

One of the most important features of Borrelia species is their genetic and antigenic variability. The bacterium is able to constantly modify its surface proteins, making it difficult for the immune system to detect in a stable way. This mechanism may contribute to the persistence of the infection in the body and to the fact that the immune response does not always follow the classical pattern.<\/p>\n\n\n\n

The role of co-infections in the clinical picture<\/h2>\n\n\n\n

Ticks may not only carry Borrelia bacteria. Often, a single bite can introduce several pathogens into the body. These are called co-infections and can have a significant impact on clinical signs and diagnostic results.<\/p>\n\n\n\n

The most commonly cited co-infections include:<\/p>\n\n\n\n